It's an important game, with both sides still aiming to qualify for Europe through league position.
A place in the Premier League's top seven is required to do that but United currently sit eighth, three points behind the Magpies, with two games to play.
Chelsea, who travel to Brighton & Hove Albion on Wednesday, are still in the equation too, but as our goal difference is inferior to our two challengers, three points are needed on Wednesday to take the fight to the final day.
There are doubts around several Reds ahead of the game, and Ten Hag has admitted that he is having to find a balance between ensuring players are ready to return and giving them enough game-time before the Emirates FA Cup final on 25 May.